AubreyWatch

What is this?
I am extremely motivated to see technology advance to the point we can extend human life expectancy, considerably, and eventually roll back most and then all pathology of what constitutes “aging”. That means – I want all people [who want to] to be capable of living indefinitely, very few caveats. I think this isn’t merely ‘good’, it’s critical. I believe short term policy and self-interested goals (and voting) of people who all think they’ll be dead in a few decades is literally destroying the planet. If people had a reasonable expectation of living centuries they’d actually go and give a damn about the future. To that end I support this ‘ecology of progress’, and befriended Aubrey de Grey and his cavalcade of supporters way back in 2005. Later I started a link depository (suppository?) at scoop.it to that end, but then the facebook goons put the thumbscrews on scoop {/conspiracy theory} and scoop started cutting down access to my own scoops significantly. I am thus discontinuing my presence there and transferring those links to my blog hereabouts. Thank you scoop.it, fuck you very much.


2018 May

Inflammation, But Not Telomere Length, Predicts Successful Ageing at Extreme Old Age: A Longitudinal Study of Semi-supercentenarians


Is It Moral to Seek Immortality? A Discussion at the Vatican

Longevity enables a variety of positive externalities. Why retire at 70 years old, at the peak of your earning capacity, when you could potentially contribute to society for another 30+ years? Extending the human lifespan by 30 years—and postponing the retirement age—would generate the biggest global GDP boom ever. Regardless of your religious beliefs, you’ll soon have the option to take advantage of life-extending technology. And if you don’t want to live to 250, you don’t have to. In closing, I found it promising that all the religious leaders on my panel agreed that adding a healthy extra 30 years would be desirable. I agreed and said, “I’m happy with an age-span target of 120 healthy years, after that we can negotiate another extension.”


The Thing Inside Your Cells That Might Determine How Long You Live

You may have forgotten about the nucleolus since you took biology class, but scientists think this structure inside every cell in your body may play an important role in aging.


2018 April


Aging is No Laughing Matter


https://nightingalehealth.com/news/eline-slagboom-on-biological-ageing


https://medium.com/neodotlife/juvenescence-jim-mellon-longevity-e9a415dd0569


Ladies and Gentlemen, We Are All Dying






https://newatlas.com/intestinal-stem-cell-regeneration-fasting/54526/


http://www.news.com.au/technology/science/human-body/end-of-ageing-and-cancer-scientists-unveil-structure-of-the-immortality-enzyme-telomerase/news-story/051d2ef70f46088466cf4fcfa72aa99d




Reason – Fight Aging! blog and Repair Biotechnologies


View post on imgur.com



2018 April

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Dr. Josh Mitteldorf – Are we on the verge of major breakthroughs in anti-aging science?

I’m no believer in “aging gracefully.” I’m much more in the camp of “Do not go gentle into that good night–rage, rage against the dying of the light!” (Dylan Thomas). Or Edna St. Vincent Millay: “Down, down into the darkness of the grave they go… I know. But I do not approve. And I am not resigned.” – At age 68, I’m starting a new career, learning new things not just in the sense of adding to my knowledge; I’m revising old theories as new evidence comes in and overturning the way I see the world.


DNA methylation-based biomarkers and the epigenetic clock theory of ageing

Identifying and validating molecular targets of interventions that extend the human health span and lifespan has been difficult, as most clinical biomarkers are not sufficiently representative of the fundamental mechanisms of ageing to serve as their indicators. In a recent breakthrough, biomarkers of ageing based on DNA methylation data have enabled accurate age estimates for any tissue across the entire life course. These ‘epigenetic clocks’ link developmental and maintenance processes to biological ageing, giving rise to a unified theory of life course. Epigenetic biomarkers may help to address long-standing questions in many fields, including the central question: why do we age?



Alzheimer’s gene neutralised in human brain cells for the first time

Scientists have claimed an important breakthrough in the battle against Alzheimer’s after neutralising the most significant gene responsible for the disease for the first time. A team in California successfully identified the protein associated with the high-risk apoE4 gene and then managed to prevent it damaging human neuron cells.



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2018 March

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Anti-aging protein alpha Klotho’s molecular structure revealed

Researchers from UT Southwestern’s Charles and Jane Pak Center for Mineral Metabolism and Clinical Research and Internal Medicine’s Division of Nephrology recently published work in Nature that reveals the molecular structure of the so-called “anti-aging” protein alpha Klotho (a-Klotho) and how it transmits a hormonal signal that controls a variety of biologic processes. The investigation was performed in collaboration with scientists from New York University School of Medicine and Wenzhou Medical University in China.


A dietary supplement makes old mice youthful. But will it work in people?

Transfusing young blood and freezing heads may get most of the anti-aging and life-extension buzz, but don’t count out the molecule hunters: After setbacks and stumbles and what critics called debacles, these scientists are figuring out which biochemicals might potentially, possibly be fountains of youth in pill form.


Life… UNLIMITED: Beating ageing is set to become the biggest business in the world, say tycoons

Amazon founder Jeff Bezos, whose hobby is launching rockets into space, is the world’s richest man with a £90billion fortune, a Gulfstream jet and a string of mansions dotted across America. Who could blame him for wanting to live for ever? The 54-year-old internet tycoon and a handful of Silicon Valley billionaires are investing chunks of their vast wealth in efforts to extend life by slowing the ageing process.


Stem cell treatment drastically reduces drinking in alcoholic rats

After treatment, binge drinking rats became responsible drinkers. – A team of researchers has successfully treated disordered drinking in rats by injecting them with human stem cells. To conduct the study, the team led by Yedy Israel used rats selectively bred to prefer alcohol to water. Left to their own devices, the rats consumed the human equivalent of over one bottle of vodka every day for up to 17 weeks. 48 hours after treatment, they were drinking 90 percent less. We spoke with Israel about the work.


Vitalik Buterin: The Best Thing to Donate Money to is The Fight Against Aging

A few days ago, LEAF representatives attended the Undoing Aging 2018 conference in Berlin, which was jointly organized by the SENS Research Foundation and the Forever Healthy Foundation. We invited one of the most professional Russian journalists writing about aging, Anna Dobryukha, to this conference, and she will write a series of articles and interviews in Komsomolskaya Pravda (KP) over the next weeks. As these articles are interesting to the global community, we decided to translate them for our blog. Today, we publish the first article of this series, an interview that Anna conducted with Vitalik Buterin, the creator of the cryptocurrency Ethereum. Vitalik donated 2.4 million dollars to the SENS Research Foundation earlier this year, so let’s find out what Vitalik’s views are on rejuvenation biotech and life extension!


Do you want to live forever? 6 ways tech could extend your life

Death, as one of Neil Gaiman’s Vertigo comic books of the 1990s pointed out, is the high cost of living. But just because it’s always been like that doesn’t mean it has to stay that way. With that in mind, here are six ways that technology and technologists could wind up extending your lifespan, anywhere from a few decades to, well, the end of life as humankind knows it.


Why two brains are better than one

A radical technique that makes mature cells act like stem cells is growing a mini brain from tissue I donated. One day it could produce whole organs for transplant. Last week, I was told my other brain is fully grown. It doesn’t look like much. A blob of pale flesh about the size of a small pea, it floats in a bath of blood-red nutrient. It would fit into the cranium of a foetus barely a month old.



Doctors Have Restored The Sight of Two People in a Monumental World First

British physicians have successfully used stem cells to repair the degenerating tissue at the back of two patients’ eyes in a world first, effectively reversing their diminishing eyesight. It’s now hoped that an affordable form of the therapy could be made available in the UK within the next five years, opening the way for more than half a million people in the UK and millions more around the globe to have their impaired vision restored.


Scientists Discover Cause Of Vascular Aging — And How To Reverse It — In Mice

A new study led by researchers at Harvard Medical School identifies key cellular mechanisms that cause blood vessels to age. Now, they’re looking for ways to apply what they found in mice studies to human health.Here & Now’s Jeremy Hobson talks with David Sinclair (@davidasinclair), the study’s senior investigator, a professor and co-director of the Paul F. Glenn Center for the Biology of Aging at Harvard Medical School.



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A New $500 Blood Test Could Detect Cancer Before Symptoms Develop

An international team of researchers have developed a new test that screens for multiple types of cancer using only a blood sample.


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The Hallmarks of Aging

Aging is characterized by a progressive loss of physiological integrity, leading to impaired function and increased vulnerability to death. This deterioration is the primary risk factor for major human pathologies, including cancer, diabetes, cardiovascular disorders, and neurodegenerative diseases. Aging research has experienced an unprecedented advance over recent years, particularly with the discovery that the rate of aging is controlled, at least to some extent, by genetic pathways and biochemical processes conserved in evolution. This Review enumerates nine tentative hallmarks that represent common denominators of aging in different organisms, with special emphasis on mammalian aging. These hallmarks are: genomic instability, telomere attrition, epigenetic alterations, loss of proteostasis, deregulated nutrient sensing, mitochondrial dysfunction, cellular senescence, stem cell exhaustion, and altered intercellular communication. A major challenge is to dissect the interconnectedness between the candidate hallmarks and their relative contributions to aging, with the final goal of identifying pharmaceutical targets to improve human health during aging, with minimal side effects.


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